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These trials study the use of different CBD formulation in patients affected by severe forms of drug-resistant epilepsy.

The purpose of this review is to provide an overview of recent clinical trials registered on. This form of epilepsy is characterized by recurrent seizures that negatively affect the quality of life. About 30% of epilepsy patients are affected by Treatment-Resistant Epilepsy (TRE) due to the failure of common anti-epileptic therapies. In 2016, the first results of phase III clinical trials showed beneficial effects of CBD (Epidiolex В® GW Pharmaceutical, Cambridge, UK) in treatment-resistant seizure disorders, including Lennox-Gastaut Syndrome (LGS) and Dravet syndromes (DS).Д®pilepsy is a chronic neurological disorder. Several studies confirmed its efficacy in the treatment of epileptic seizures, especially in pediatric age. Moreover, for a long time, the CBD has been investigated for its anticonvulsant effects. In addition, it has been shown that CBD can significantly reduce two important forms of anxiety, namely obsessive-compulsive disorder and post-traumatic stress disorder. CBD is also generating interest due to its therapeutic properties such as antidepressant, antipsychotic, analgesic, and antitumor. The CBD also carry out a potent antioxidant activity, modulating the expression of inducible nitric oxide synthase and nitrotyrosine as well as reducing production of reactive oxygen species. The binding of CBD to TRPV1 leads to a desensitization of these receptors, with a consequent reduction in inflammation. The sensitivity but also the density of TRPV1 is increased during neuro-inflammatory conditions. TRPV1 receptor is a nonselective cation channel that, when activated, allows the influx of Ca 2+.

Furthermore, another mechanism by which CBD performs its anti-inflammatory action is mediated by interaction with the Transient Potential Vanilloid Receptor Type 1 (TRPV1). CBD shows anti-inflammatory properties in several experimental studies, modulating some pro-inflammatory cytokines such as interleukin-1ОІ (IL-1ОІ ), interleukin-6 (IL-6) and tumor necrosis factor О± (TNF-О±), as well as regulation of cell cycle and immune cellsвЂ™ functions. This neuroprotective action is due to its anti-inflammatory and antioxidant properties. In recent years, the scientific community has shown interest in this compound due to its good safety profile and neuroprotective properties in several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis, ParkinsonвЂ™s, HuntingtonвЂ™s and AlzheimerвЂ™s diseases.

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